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mk212 hydrochloride (Tocris)

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Tocris mk212 hydrochloride
Mk212 Hydrochloride, supplied by Tocris, used in various techniques. Bioz Stars score: 92/100, based on 6 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/mk212+hydrochloride/MK+212+hydrochloride/pm34560172-52-0-15
Average 92 stars, based on 6 article reviews

mk212 hydrochloride - by Bioz Stars, 2026-09

92/100 stars

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Article Title: Oral fluoxetine treatment changes serotonergic sympatho-regulation in experimental type 1 diabetes.
Article Snippet: The drugs (and its corresponding suppliers) utilized were: fluoxetine hydrochloride (Normon; Madrid, Spain); heparin sodium (Roche; Madrid, Spain); atropine sulphate (Scharlau; Barcelona, Spain); sodium pentobarbital (Dolethal® from Vetoquinol; Madrid, Spain); d-tubocurarine hydrochloride, alloxan monohydrate, 5-HT creatinine-sulfate monohydrate, NE bitartrate, 1-phenylbiguanide (1-PBG), BW723C86, and CGS-12066B (Sigma-Aldrich; St. Louis, MO, US); 5-carboxamidotryptamine maleate (5-CT), 8-OH-DPAT, L-694,247, α-methyl-5-hydroxytryptamine maleate (α-methyl-5-HT), ritanserin, MK212 hydrochloride, WAY-100,635, and LY310762 (Tocris Bioscience; Bristol, UK). .. A

Article Title: Vascular sympathetic neurotransmission and its serotonergic regulation are modified by chronic fluoxetine treatment.
Article Snippet: The compounds utilized were: fluoxetine hydrochloride (Normon; Madrid, Spain); heparin sodium (Roche; Madrid, Spain); atropine sulphate (Scharlau; Barcelona, Spain); prazosin (Pfizer; New York, US); pentobarbital sodium, 5-HT creatinine-sulfate monohydrate, NA bitartrate, 1-phenylbiguanide (1-PBG), BW723C86, and CGS-12066B (SigmaeAldrich; St. Louis, MO, US); 5- carboxamidotryptamine maleate (5-CT), 8-OH-DPAT, L-694,247, amethyl-5-hydroxytryptamine maleate (a-methyl-5-HT), SB269970, ritanserin, MK212 hydrochloride, WAY-100,635, and LY310762 (Tocris Bioscience; Bristol, UK).. All drugs were dissolved in saline, except ritanserin (in 0.04 M lactic acid).All drugs were dissolved in saline, except ritanserin (in 0.04 M lactic acid).

Article Title: Acquisition session length modulates consolidation effects produced by 5–HT 2C ligands in a mouse autoshaping-operant procedure
Article Snippet: MK212 hydrochloride, mCPP hydrochloride, and methy-sergide maleate (Tocris Bioscience, Ellisville, Missouri, USA), mianserin hydrochloride, SB 206 553 hydrochloride (Sigma Aldrich, St. Louis, Missouri, USA), and BOL (National Institute on Drug Abuse, Bethesda, Maryland, USA).. All drugs were dissolved with either saline or sterile water for injection and injected intraperitoneally.All drugs were dissolved with either saline or sterile water for injection and injected intraperitoneally.

Article Title: Repeated administration of 5-hydroxytryptamine 2C agonist MK212 produces a sensitization effect of antipsychotic activity.
Article Snippet: MK212 hydrochloride (6-Chloro-2-(1-piperazinyl)pyrazine hydrochloride, CAS 61655-58-1, Tocris Bioscience Co., Bristol, United Kingdom) was selected on the basis of extensive literature review indicating its agonist-preferential action at the 5- HT2C receptor (26,27). .. T

Article Title: Role of dorsal medial prefrontal cortex dopamine D1-family receptors in relapse to high-fat food seeking induced by the anxiogenic drug yohimbine.
Article Snippet: SCH23390 hydrochloride and MK212 hydrochloride were purchased from Tocris (Ellisville, MO), yohimbine hydrochloride was purchased from Sigma (St Louis, MO), and M100907 was provided by Dr Kenner Rice (NIDA).. SCH23390 (injection volume of 1ml/kg or 0.5 ml/side for systemic or intracranial injections, respectively) and MK212 (0.5 ml/side) were dissolved in sterile saline; M100907 (0.5 ml/side) was dissolved in a minimal volume of 0.01N HCl and sterile saline and the pH of the solution was adjusted to 6–7 with 0.1 N NaOH.SCH23390 (injection volume of 1ml/kg or 0.5 ml/side for systemic or intracranial injections, respectively) and MK212 (0.5 ml/side) were dissolved in sterile saline; M100907 (0.5 ml/side) was dissolved in a minimal volume of 0.01N HCl and sterile saline and the pH of the solution was adjusted to 6–7 with 0.1 N NaOH.

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Central administration of serotonin (5HT) and serotonin-2C receptor (5HT2CR) agonist stimulated GnRH pulse generator activity, and 5HT2CR antagonism blocked the 5HT-induced stimulation of GnRH pulse generator activity recorded by multiple unit activity (MUA) in the ARC of OVX goats. ( a ) Schematic illustration of the experimental procedure for determining the effects of lateral ventricle (LV) administration of 5HT and 5HT2CR agonist and antagonist on MUA volley in goats. 5HT and MK212, a 5HT2CR agonist, were injected into the LV at a half-time of the mean interval of MUA volleys (Tm/2) determined by the 5-h prerecording of MUA. SB206553 (SB), a 5HT2CR antagonist, was infused into the LV immediately after the second MUA volley until the 5HT injection at Tm/2 after the third MUA volley. ( b ) Profiles of MUA volleys and LH pulses in representative goats treated with 5HT or Veh (arrows). Arrow heads indicate the peaks of LH pulses identified by the PULSAR computer program. ( c ) The mean MUA volley interval of OVX goats after central 5HT (0.5 or 5 µmol) administration was significantly ( p < 0.05) shortened compared with that of Veh-treated control goats. ( d ) Percent change in mean LH levels of OVX goats after central 5HT (5 µmol) administration significantly ( p < 0.05) increased compared with that of Veh-treated controls. ( e ) Profiles of MUA volleys and LH pulses of representative goats treated with LV infusion of SB (green) or Veh (gray) and LV injection of 5HT (arrows). ( f ) The mean MUA volley intervals at the postinfusion period were significantly ( p = 0.0026) shortened by 5HT injection in the Veh-treated group (gray), whereas the interval at the postinfusion period significantly ( p = 0.0026) elongated in the SB-treated group (green). In addition, significant differences were found in the MUA volley interval between the SB + 5HT and Veh + 5HT groups during the postinfusion period ( p = 0.0037). ( g ) The percent change in mean LH levels in OVX goats treated with LV infusion of SB (green) or Veh (gray). ( h ) Profiles of MUA volleys and LH pulse of representative OVX goats treated with LV administration of MK212 (0.5 or 5 µmol) or Veh (arrows). ( i ) The mean MUA volley interval of OVX goats treated with central administration of MK212 (5 µmol) was significantly shorter than that of Veh-treated controls ( p = 0.0022). ( j ) The percent change in mean LH levels in OVX goats treated with LV administration of MK212 (0.5 or 5 µmol) or Veh. Values are means ± SEMs. The numbers in each column indicate the number of animals used. Arrowheads indicate the peaks of LH pulses identified by the PULSAR computer program.

Journal: Scientific Reports

Article Title: Raphe glucose-sensing serotonergic neurons stimulate KNDy neurons to enhance LH pulses via 5HT2CR: rat and goat studies

doi: 10.1038/s41598-024-58470-4

Figure Lengend Snippet: Central administration of serotonin (5HT) and serotonin-2C receptor (5HT2CR) agonist stimulated GnRH pulse generator activity, and 5HT2CR antagonism blocked the 5HT-induced stimulation of GnRH pulse generator activity recorded by multiple unit activity (MUA) in the ARC of OVX goats. ( a ) Schematic illustration of the experimental procedure for determining the effects of lateral ventricle (LV) administration of 5HT and 5HT2CR agonist and antagonist on MUA volley in goats. 5HT and MK212, a 5HT2CR agonist, were injected into the LV at a half-time of the mean interval of MUA volleys (Tm/2) determined by the 5-h prerecording of MUA. SB206553 (SB), a 5HT2CR antagonist, was infused into the LV immediately after the second MUA volley until the 5HT injection at Tm/2 after the third MUA volley. ( b ) Profiles of MUA volleys and LH pulses in representative goats treated with 5HT or Veh (arrows). Arrow heads indicate the peaks of LH pulses identified by the PULSAR computer program. ( c ) The mean MUA volley interval of OVX goats after central 5HT (0.5 or 5 µmol) administration was significantly ( p < 0.05) shortened compared with that of Veh-treated control goats. ( d ) Percent change in mean LH levels of OVX goats after central 5HT (5 µmol) administration significantly ( p < 0.05) increased compared with that of Veh-treated controls. ( e ) Profiles of MUA volleys and LH pulses of representative goats treated with LV infusion of SB (green) or Veh (gray) and LV injection of 5HT (arrows). ( f ) The mean MUA volley intervals at the postinfusion period were significantly ( p = 0.0026) shortened by 5HT injection in the Veh-treated group (gray), whereas the interval at the postinfusion period significantly ( p = 0.0026) elongated in the SB-treated group (green). In addition, significant differences were found in the MUA volley interval between the SB + 5HT and Veh + 5HT groups during the postinfusion period ( p = 0.0037). ( g ) The percent change in mean LH levels in OVX goats treated with LV infusion of SB (green) or Veh (gray). ( h ) Profiles of MUA volleys and LH pulse of representative OVX goats treated with LV administration of MK212 (0.5 or 5 µmol) or Veh (arrows). ( i ) The mean MUA volley interval of OVX goats treated with central administration of MK212 (5 µmol) was significantly shorter than that of Veh-treated controls ( p = 0.0022). ( j ) The percent change in mean LH levels in OVX goats treated with LV administration of MK212 (0.5 or 5 µmol) or Veh. Values are means ± SEMs. The numbers in each column indicate the number of animals used. Arrowheads indicate the peaks of LH pulses identified by the PULSAR computer program.

Article Snippet: An 18-G stainless steel guide cannula was implanted in the LV for intracerebroventricular administration of serotonin hydrochloride (Sigma‒Aldrich), MK212 hydrochloride (a selective 5HT2CR agonist; R&D Systems), or SB206553 hydrochloride (5HT2B/2CR antagonist; Santa Cruz Biotechnology) as described previously .

Techniques: Activity Assay, Injection, Control

Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), MK212 (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.

Journal: Behavioural pharmacology

Article Title: Acquisition session length modulates consolidation effects produced by 5–HT 2C ligands in a mouse autoshaping-operant procedure

doi: 10.1097/FBP.0b013e328337bde7

Figure Lengend Snippet: Effects of saline and 5–HT2C ligands on the consolidation of autoshaped-operant reinforced and nonreinforced responding in mice after 1-h (white bars) and 2-h (black bars) acquisitions sessions on day 1. Vertical axis: left panel, mean-adjusted latency defined as the latency to the tenth minus the latency to the first reinforced response; middle panel, rate of overall dipper hole nose-poke responses per second; right panel, rate of left and right nose-poke responding as a measure of nonreinforced activity. Horizonrtal axis: saline, drugs and doses in mg/kg, administered intraperitoneally. 1-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.001), MK212 (P < 0.01), SB206 553 (P < 0.01), BOL (P < 0.05) and methysergide (P < 0.01) (left panel); reduced rates of reinforced responding relative to saline (P < 0.01) and 10 mg/kg SB206 553 (P < 0.01) (middle panel); MK212 increased nonreinforced response rates relative to 32 mg/kg mianserin (P < 0.05) and methysergide (P < 0.05) (right panel). 2-h acquisition session: 32 mg/kg mianserin increased day 2 mean latency relative to saline controls (P < 0.05) and all other agents tested (P < 0.05) (left panel); reduced rates of reinforced responding compared with saline controls (P < 0.05), m-chlorophenylpiperazine (mCPP) (P < 0.01), 3.2 mg/kg SB206 553 (P < 0.05) and methysergide (P < 0.01) (middle panel); 10 mg/kg SB206 553 significantly altered rates of nonreinforced responding relative to saline controls, (P < 0.05), MK212 (P < 0.01), mCPP (P < 0.05) and 32 mg/kg mianserin (P < 0.05) (right bars). Number of mice tested during the 1- and 2-h acquisition session, respectively: saline (n = 11, 10), MK212 (n = 5, 5), mCPP (n = 11, 12), (10 mg/kg n = 6, 6; 32 mg/kg n = 6, 9), SB206 553 (3.2 mg/kg n = 6, 4; 10 mg/kg n = 11, 5), BOL (n = 5, 7), and methysergide (n = 5, 9). Twelve mice failed to earn five (1 h) or 10 (2 h) reinforcers during the day 1aquisition session. Vertical bars represent SEM *P < 0.05; **P < 0.01; ***P < 0.001.

Article Snippet: Drugs MK212 hydrochloride, mCPP hydrochloride, and methy-sergide maleate (Tocris Bioscience, Ellisville, Missouri, USA), mianserin hydrochloride, SB 206 553 hydrochloride (Sigma Aldrich, St. Louis, Missouri, USA), and BOL (National Institute on Drug Abuse, Bethesda, Maryland, USA).

Techniques: Saline, Activity Assay

Effects of systemic MK212 (2.0 mg/kg) on maternal behavior under 4-h pup-separation (PS, pups were taken away from dams 4 h before the test) and no-pup-separation (NS) conditions on PP 4 and 6. On each test day, maternal behavior was observed for 10 min at 4 time points: 0.5 h before, 0.5, 2 and 4 h after the injection. On PP 4, mother rats were tested under two separation conditions. On PP 6, the rats tested in the pup-separation condition on Day 4 were tested in the no-pup-separation condition, and those previously tested in the no-pup-separation condition were tested in the pup-separation condition. Data from the postpartum day 4 and 6 under the same condition (PS or NS) are combined and expressed as mean ± SEM. A, number of pup retrieved; B, latency of first pup retrieved; C, duration of pup nursing; D, duration of pup licking; E, duration of nest building; F, duration of pup sniffing. ** p < 0.01, * p < 0.05 significantly different between the different drug administrations (VEH vs. MK212) within the same separation condition (PS or NS); ## p < 0.01, # p < 0.05 significantly different between the different separation conditions (PS vs. NS) within the same drug exposure (VEH or MK212).

Journal: Psychoneuroendocrinology

Article Title: Behavioral, Pharmacological and Neuroanatomical Analysis of Serotonin 2C Receptor Agonism on Maternal Behavior in Rats

doi: 10.1016/j.psyneuen.2016.08.017

Figure Lengend Snippet: Effects of systemic MK212 (2.0 mg/kg) on maternal behavior under 4-h pup-separation (PS, pups were taken away from dams 4 h before the test) and no-pup-separation (NS) conditions on PP 4 and 6. On each test day, maternal behavior was observed for 10 min at 4 time points: 0.5 h before, 0.5, 2 and 4 h after the injection. On PP 4, mother rats were tested under two separation conditions. On PP 6, the rats tested in the pup-separation condition on Day 4 were tested in the no-pup-separation condition, and those previously tested in the no-pup-separation condition were tested in the pup-separation condition. Data from the postpartum day 4 and 6 under the same condition (PS or NS) are combined and expressed as mean ± SEM. A, number of pup retrieved; B, latency of first pup retrieved; C, duration of pup nursing; D, duration of pup licking; E, duration of nest building; F, duration of pup sniffing. ** p < 0.01, * p < 0.05 significantly different between the different drug administrations (VEH vs. MK212) within the same separation condition (PS or NS); ## p < 0.01, # p < 0.05 significantly different between the different separation conditions (PS vs. NS) within the same drug exposure (VEH or MK212).

Article Snippet: MK212 [6-Chloro-2-(l-piperazinyl) pyrazine hydrochloride] and SB242084 [6-Chloro-2,3-dihydro-5-methyl-N-[6-[(2-methyl-3-pyridinyl)oxy]-3-pyridiny]-1H-indole-1-carboxyamide dihydrochloride hydrate] were obtained from Tocris Bioscience (Ellisville, MO, USA).

Techniques: Injection

Effects of systemic MK212 (2.0 mg/kg) on food retrieval under 6-h food-deprivation (FD) and no-food-deprivation (ND) conditions on postpartum day 8 and 10. Each retrieval test lasted 10 min. Number (A) and latency (B) of food retrieval from the postpartum day 8 and 10 under the same condition (FD or ND) are combined and expressed as mean + SEM. * p < 0.05, ** p < 0.01 significantly different between the different drug administrations (VEH vs. MK212) within the same deprivation treatment (FD or ND).

Journal: Psychoneuroendocrinology

Article Title: Behavioral, Pharmacological and Neuroanatomical Analysis of Serotonin 2C Receptor Agonism on Maternal Behavior in Rats

doi: 10.1016/j.psyneuen.2016.08.017

Figure Lengend Snippet: Effects of systemic MK212 (2.0 mg/kg) on food retrieval under 6-h food-deprivation (FD) and no-food-deprivation (ND) conditions on postpartum day 8 and 10. Each retrieval test lasted 10 min. Number (A) and latency (B) of food retrieval from the postpartum day 8 and 10 under the same condition (FD or ND) are combined and expressed as mean + SEM. * p < 0.05, ** p < 0.01 significantly different between the different drug administrations (VEH vs. MK212) within the same deprivation treatment (FD or ND).

Techniques:

Effects of acute MK212 (2.0 mg/kg) treatment on pup retrieval with pretreatment of SB242084 (0, 0.6, 1.0 mg/kg). SB242084 was injected 10 min before the MK212. Maternal behavior was tested for 10 min at 30 min before, 30 min, 60 min and 24 h after MK212 injection. Number of pups retrieved in each test is expressed as mean + SEM. ** p < 0.01 significantly different between the VEH-1 + VEH and − MK212 groups. # p < 0.05 significantly different between SB242084 + MK212 and VEH-1 + MK212 groups.

Journal: Psychoneuroendocrinology

Article Title: Behavioral, Pharmacological and Neuroanatomical Analysis of Serotonin 2C Receptor Agonism on Maternal Behavior in Rats

doi: 10.1016/j.psyneuen.2016.08.017

Figure Lengend Snippet: Effects of acute MK212 (2.0 mg/kg) treatment on pup retrieval with pretreatment of SB242084 (0, 0.6, 1.0 mg/kg). SB242084 was injected 10 min before the MK212. Maternal behavior was tested for 10 min at 30 min before, 30 min, 60 min and 24 h after MK212 injection. Number of pups retrieved in each test is expressed as mean + SEM. ** p < 0.01 significantly different between the VEH-1 + VEH and − MK212 groups. # p < 0.05 significantly different between SB242084 + MK212 and VEH-1 + MK212 groups.

Techniques: Injection

Effects of MK212 microinfused into the nucleus accumbens shell (NAs, A) on pup retrieval throughout the four test days (PP 3, 5, 7 and 9). Effects of MK212 microinfused into the medial preoptic area (MPOA, B) or medial prefrontal cortex (mPFC, C) on pup retrieval throughout the four test days (PP 4, 6, 8 and 10). Number of pups retrieval in each test is expressed as mean + SEM.

Journal: Psychoneuroendocrinology

Article Title: Behavioral, Pharmacological and Neuroanatomical Analysis of Serotonin 2C Receptor Agonism on Maternal Behavior in Rats

doi: 10.1016/j.psyneuen.2016.08.017

Figure Lengend Snippet: Effects of MK212 microinfused into the nucleus accumbens shell (NAs, A) on pup retrieval throughout the four test days (PP 3, 5, 7 and 9). Effects of MK212 microinfused into the medial preoptic area (MPOA, B) or medial prefrontal cortex (mPFC, C) on pup retrieval throughout the four test days (PP 4, 6, 8 and 10). Number of pups retrieval in each test is expressed as mean + SEM.

Techniques:

A c-Fos immunohistochemistry study for the MK212 (2.0mg/kg) effects on maternal behavior. (A) Effects of repeated MK212 administration on the number of pup retrieved. Maternal behavior was tested for 10 min once daily from PP 6 to 9, with starting at 30 min after drug injection. (B) Effects of acute and repeated MK212 administration on c-Fos immunoreactivity. On PP 10, all rats were overdosed and perfused and their brains were extracted for c-Fos immunoreactivity staining 1 h after the drug injection. Number of anti-c-Fos positive cells is expressed as mean + SEM. ** p < 0.01, * p < 0.05 significantly different between the VEH and MK212 in the same regimen (acute or repeated drug exposure); # p < 0.05, ## p < 0.01 significantly different between the acute and repeated drug treatment in the same treatment condition (VEH or MK212). LSv, ventral lateral septum; CeA, central amygdala; MPOA, medial preoptic area; DG, dentate gyrus; DR, dorsal raphe; VTA, ventral tegmental area. (C), photomicrographs of immunohistochemistry showing c-Fos expression in the dorsal raphe. In comparison to the VEH groups, MK212 reduced the number of c-Fos immunoreactive neurons under both acute and repeated administration. (1), acute VEH; (2), acute 2.0mg/kg MK212; (3), repeated VEH; (4), repeated 2.0mg/kg MK212. Scale bar =100 μm.

Journal: Psychoneuroendocrinology

Article Title: Behavioral, Pharmacological and Neuroanatomical Analysis of Serotonin 2C Receptor Agonism on Maternal Behavior in Rats

doi: 10.1016/j.psyneuen.2016.08.017

Figure Lengend Snippet: A c-Fos immunohistochemistry study for the MK212 (2.0mg/kg) effects on maternal behavior. (A) Effects of repeated MK212 administration on the number of pup retrieved. Maternal behavior was tested for 10 min once daily from PP 6 to 9, with starting at 30 min after drug injection. (B) Effects of acute and repeated MK212 administration on c-Fos immunoreactivity. On PP 10, all rats were overdosed and perfused and their brains were extracted for c-Fos immunoreactivity staining 1 h after the drug injection. Number of anti-c-Fos positive cells is expressed as mean + SEM. ** p < 0.01, * p < 0.05 significantly different between the VEH and MK212 in the same regimen (acute or repeated drug exposure); # p < 0.05, ## p < 0.01 significantly different between the acute and repeated drug treatment in the same treatment condition (VEH or MK212). LSv, ventral lateral septum; CeA, central amygdala; MPOA, medial preoptic area; DG, dentate gyrus; DR, dorsal raphe; VTA, ventral tegmental area. (C), photomicrographs of immunohistochemistry showing c-Fos expression in the dorsal raphe. In comparison to the VEH groups, MK212 reduced the number of c-Fos immunoreactive neurons under both acute and repeated administration. (1), acute VEH; (2), acute 2.0mg/kg MK212; (3), repeated VEH; (4), repeated 2.0mg/kg MK212. Scale bar =100 μm.

Techniques: Immunohistochemistry, Injection, Staining, Expressing, Comparison

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